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KMID : 1007520030120050544
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Food Science and Biotechnology
2003 Volume.12 No. 5 p.544 ~ p.547
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Effect of Chongkukjang on Blood Glucose and Lipid Profile in Neonatal Streptozotocin-induced Diabetic Rats
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Kang, Min-Jung
Kim, Jung-In/Kwon, Tai-Wan
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Abstract
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Keeping blood glucose levels as close to normal and preventing diabetc complications are the major goals of diabetes mellitus treatment. Hyperlipidemia is one of the many risk factors of cardiovascular diseases-the most common diabetic complication. We studied the effects of feeding Chongkukjang-a fermented soybean product on carbohydrate and lipid metabolisms in neonatal streptozotocin-induced diabetic rats. To induce type 2 diabetes, a single dose of 5-day-old Sprague-Dawley rats. Ten-week-old rats were randomly divided into two groups and fed basal diet or Chongkukjang-containing diet for 8 wks, after which they were tested for glucose tolerance. The incremental blood glucose level was lower in the Chongkukjang group than in the control group at 60 min after oral administration of glucose (1 g／㎏). The fasting plasma glucose level was significantly lower in the Chongkukjang group (202.1±17.6 ㎎／dL) than in the control group (253.9±11.7 ㎎／dL. Feeding Chongkukjang significantly decrease plasma triglyceride (67.3±4.3㎎／dL) and cholesterol (98.8±8.5㎎／dL) levels, compared with the control group (80.8±4.0㎎／dL and 137.4±11.0㎎／dL, respectively). The HDL-cholesterol level of the Chongkukjang group was not significantly different from that of the control group. Therefore, long term feeding of Chongkukjang had hypoglycemic and hypolipidemic effects in an animal model of type 2 diabetes mellitus.
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KEYWORD
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